spybot,adaware, old news they have been covered here many many times, good programs but the best way is to avoid getting infected in the first place.avg as you mention for antivirus also do a free spyware checker/blocker obviously prevention is better than a cure.with regards to easy cleaner also useful but shouldnt need to be run that often unless you install uninstall many programs and delete loads of files regularly.as far your order of running these apps it would make more sense to run adaware and spybot before running easy cleaner and defrag once a month.